1-BOC-4-(PIPERIDIN-4-YL)-PIPERAZINE synthesis
- Product Name:1-BOC-4-(PIPERIDIN-4-YL)-PIPERAZINE
- CAS Number:205059-24-1
- Molecular formula:C14H27N3O2
- Molecular Weight:269.38
926904-28-1
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205059-24-1
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Yield:205059-24-1 86%
Reaction Conditions:
with hydrogen;5% Pd(II)/C(eggshell) in tetrahydrofuran;water for 16 h;
Steps:
1.b
b. Intermediate 3 (101 g, 255 mmol) was given to THF (1 L), Pd/C-5% (22.0 g, 52,3 % water) was added. It was stirred under hydrogen atmosphere and standard pressure for 16 h. Ca. 6 L hydrogen were used up. The reaction mixture was filtrated and concentrated in vacuo until dryness. The yellowish-oily product 4 crystallized slowly und was used without further processing (58.9 g, 219 mmol, 86%).
References:
MERCK PATENT GMBH;SCHIEMANN, Kai;SCHULTZ, Melanie;STAEHLE, Wolfgang WO2010/115491, 2010, A2 Location in patent:Page/Page column 84-85
![1-Piperazinecarboxylic acid, 4-[1-(phenylmethyl)-4-piperidinyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/205059-23-0.gif)
205059-23-0
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205059-24-1
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57260-71-6
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205059-24-1
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19099-93-5
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205059-24-1
130 suppliers
$45.00/50mg