ChemicalBook CAS DataBase List 1-BOC-5-AMINO-INDAZOLE

1-BOC-5-AMINO-INDAZOLE synthesis

4synthesis methods

Product Name:1-BOC-5-AMINO-INDAZOLE
CAS Number:129488-10-4
Molecular formula:C12H15N3O2
Molecular Weight:233.27

5401-94-5 Synthesis

5401-94-5
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$14.00/5g

129488-10-4
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$9.00/250mg

Yield:129488-10-4 100%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol for 23 h;

Steps:

105
A suspension of 10% Pd-C (0.054 g, 0.051 mmol in Pd) and the above carbamate Example 105 (2.647 g, 10.1 mmol) in 95% EtOH was degassed under reduced pressure then reacted under hydrogen. After 23 h the solvent was evaporated on a rotary evaporator. EtOAc (20 mL) was added and the reaction filtered then slowly EPO concentrated on a rotary evaporator yielding 2.335 g (100%) of a tan solid.LC- MS (ESI) m/z 134 [M-Boc+H]⁺.

References:

MYRIAD GENETICS, INC. WO2006/135383, 2006, A2 Location in patent:Page/Page column 123-124

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