ChemicalBook CAS DataBase List 1-BroMo-2,3,4-trichlorobenzene

1-BroMo-2,3,4-trichlorobenzene synthesis

5synthesis methods

Product Name:1-BroMo-2,3,4-trichlorobenzene
CAS Number:81067-37-0
Molecular formula:C6H2BrCl3
Molecular Weight:260.34

87-61-6
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$14.00/25g

81067-37-0
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$484.80/250mg

Yield:81067-37-0 93.5%

Reaction Conditions:

with N-Bromosuccinimide;sulfuric acid at 10 - 30; for 0.5 h;Temperature;

Steps:

3 Example 3

300 mL of sulfuric acid was poured into a dry 500 mL four-necked flask,54.5 g of 1,2,3-trichlorobenzene were added portionwise with stirring,After complete dissolution, 60.0 g of NBS was added portionwise at 10-30 ° C,After the temperature is raised, the temperature is raised and the GC trace test is carried out. When the content of 1,2,3-trichlorobenzene is less than or equal to 2%, the bromination reaction is finished.(2) The mixture prepared in the step (1) was poured into 1500 mL of an ice-water mixture,Separate the oil layer,Washed with 300mL cold water three times, the precipitation of light yellow granular solid, filtration, drying and weighing, in 73.1g of 1-bromo-2,3,4-trichlorobenzene content of 95.739% (GC ), The molar yield was 93.5% (calculated as 1,2,3-trichlorobenzene), and the melting range was 56.8 ~ 59.6 .

References:

CN106278860,2017,A Location in patent:Paragraph 0043; 0044; 0045

634-67-3 Synthesis