1-Bromo-2,5-difluorobenzene synthesis
- Product Name:1-Bromo-2,5-difluorobenzene
- CAS Number:399-94-0
- Molecular formula:C6H3BrF2
- Molecular Weight:192.99
540-36-3
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399-94-0
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Yield:399-94-0 92.7%
Reaction Conditions:
with N-Bromosuccinimide;sulfuric acid at 30 - 40; for 1 h;Large scale;
Steps:
1.1; 2.1 (1) Bromination reaction:
Add 1000 g of p-difluorobenzene to the reaction vessel, 5000 mL of sulfuric acid, controlled to 30 °C in a water bath. 1620 g of N-bromosuccinimide was slowly added with stirring. Do not exceed 40 °C during the addition. After the addition, the reaction was incubated for 1 h and the GC was followed until the reaction was over. After the reaction, the reaction product was poured into ice water to precipitate a solid, which was suction filtered. 1568 g of 2,5-difluorobromobenzene was obtained as a pale yellow powdery solid, the content was 98%, and the yield was 92.7%.
References:
CN109369412,2019,A Location in patent:Paragraph 0009; 0013
108-86-1
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1072-85-1
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399-94-0
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1073-06-9
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348-61-8
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460-00-4
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540-36-3
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$10.00/5g
399-94-0
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$6.00/5g
327-51-5
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128259-70-1
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