1-Bromo-2-(dimethoxymethyl)-4-nitrobenzene synthesis
- Product Name:1-Bromo-2-(dimethoxymethyl)-4-nitrobenzene
- CAS Number:115972-68-4
- Molecular formula:C9H10BrNO4
- Molecular Weight:276.08
Yield:115972-68-4 97%
Reaction Conditions:
with toluene-4-sulfonic acid in methanol; for 8 h;Reflux;
Steps:
A90 Preparation of intermediate 628
In a round bottom flask, 2-bromo-5-nitrobenzene carbaldehyde (29.17g , 0.127 mol), trimethyl orthoformate (2 lmL, 0.192 mol), p-toluenesulfonic acid monohydrate (2.4g 12.6 mmol) were mixed in MeOH (600mL). Then, the reaction mixture was refluxedfor 8 hours. The reaction was cooled down and the solvent was removed. The residue was taken up with water, K2C03 and DCM. The organic layer was separated, dried over MgSO4, filtered and evaporated until dryness to give 34g (97%) of intermediate 628.
References:
WO2017/125530,2017,A1 Location in patent:Page/Page column 343; 344
6630-33-7
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