1-Bromo-2-fluoro-3-(1-methylethoxy)-benzene synthesis
- Product Name:1-Bromo-2-fluoro-3-(1-methylethoxy)-benzene
- CAS Number:1160293-59-3
- Molecular formula:C9H10BrFO
- Molecular Weight:233.08
156682-53-0
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Yield:1160293-59-3 92%
Reaction Conditions:
with potassium carbonate in acetone at 60; for 14 h;Inert atmosphere;
Steps:
181a 181 a) 1 -Bromo-2-fluoro-3-isopropoxybenzene
181 a) 1 -Bromo-2-fluoro-3-isopropoxybenzene A solution of 3-bromo-2-fluorophenol (565 mg, 2.96 mmol) in acetone (20 mL) was added 2-bromopropane (728 mg, 5.92 mmol) and K2C03 (818 mg, 5.92 mmol) slowly under nitrogen at room temperature. The reaction mixture was stirred at 60 °C for 14 h. 1 0 mL of water was added and extracted with ethyl acetate (3x). The combined organic phase was concentrated under a stream of nitrogen at 50 °C to obtain the title compound 1 - bromo-2-fluoro-3-isopropoxybenzene (700 mg , 2.73 mmol, 92 % yield) which was used for next step without further purification.
References:
WO2017/60854,2017,A1 Location in patent:Page/Page column 462
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