1-Bromo-3,5-diphenoxybenzene synthesis
- Product Name:1-Bromo-3,5-diphenoxybenzene
- CAS Number:41318-73-4
- Molecular formula:C18H13BrO2
- Molecular Weight:341.2
Yield:41318-73-4 119 g
Reaction Conditions:
with potassium carbonate in 1-methyl-pyrrolidin-2-one at 150; for 48 h;Inert atmosphere;
Steps:
1 Step 1
Under nitrogen, potassium carbonate (358 g, 2591 mmol) and NMP (661 mL) were added to a 3-necked 2L flask equipped with a mechanical stirrer, thermowell and water condenser. The resulting mixture was stirred and phenol (107 g, 1140 mmol) was slowly added in portions. Then 1-bromo-3,5-difluorobenzene (100 g, 518 mmol) was added and the mixture was heated to 150°C for 2 days. After cooling to room temperature, the mixture was poured into ice cold water (2.5 L). The resulting solid was collected by suction filtration and wet milled with MeOH (2×1 L). The white solid was further wet-milled in water (500 mL) and then wet-milled in MeOH (500 mL) to obtain 119 g (349 mmol) 1-bromo-3,5-diphenoxybenzene.
References:
CN112707923,2021,A Location in patent:Paragraph 0348-0349
