1-BROMO-3-CHLORO-2-FLUOROBENZENE synthesis

Yield:-

Reaction Conditions:

with sulfuric acid;sodium nitrite;copper(I) bromide in water

Steps:

II.1 Example II-1
STR14 To 80 ml of a 65% strength sulphuric acid are added at room temperature dropwise with stirring 14.6 g (0.1 mol) of 2-fluoro-3-chloroaniline, the mixture is cooled to 0° C., a solution of 11 g (0.16 mol) sodium nitrite in 30 ml of water is added dropwise, with stirring at 5° C. for 30 minutes afterwards, and then this solution is added in portions to as mixture of 45 ml of 48% strength hydrobromic acid and 2.8 g of copper(I) bromide. The reaction mixture is stirred for one hour at room temperature and then for 90 minutes at 90° C. For work-up the reaction solution is cooled, diluted with 200 ml of water, extracted three times with a total of 300 ml of methyl tert-butyl ether, washed with water, dried over sodium sulphate and freed from the solvent in vacuo. 21 g (97% of theory) of 1-bromo-3-chloro-2-fluorobenzene are obtained of melting point 43° C. and of boiling point 88° C. to 92° C. at 32 mbar.

References:

Bayer Aktiengesellschaft US5258526, 1993, A

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