1-bromo-3-(chloromethyl)-2-fluorobenzene synthesis

Yield:786652-60-6 99%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in toluene at 90; for 0.5 h;

Steps:

To a solution of 3-BROMO-2-FLUOROPHENYL) METHANOL (820 mg, 4. 00MMOL) in toluene (10 mL was added thionyl chloride (0. 44 mL, 6. 00 MMOL) and two drops of DMF. The reaction mixture was heated at 90°C for 30 min, cooled to rt and concentrated down to afford intermediate 1-BROMO-3- (CHLOROMETHYL)-2-FLUOROBENZENE (890 mg, 99%).'H-NMR (DMSO-d6) 8 7. 71 (m, 1 H), 7. 53 (m, 1 H), 7. 17 (m, 1 H), 4. 82 (d, 2H).

References:

WO2004/94376,2004,A1 Location in patent:Page 305-306