1-bromo-4-cyclobutyl-benzene synthesis

Yield:39868-71-8 100%

Reaction Conditions:

with triethylsilane;boron trifluoride diethyl etherate in dichloromethane at -70 - -10;

Steps:

1.2 Step 2:

Step 2: (0138) (0139) 13 g (0.057 mol) (1-a) was dissolved in 130 ml dichloromethane, and cooled to -70° C. with stirring. 15 g (0.132 mol) triethyl silicane was added dropwise. Then, 19 g (0.132 mol) boron trifluoride etherate was added dropwise to eliminate the hydroxyl group, whereby the solid was gradually dissolved. After addition, the solution was naturally warmed to -10° C. and poured into 100 ml aqueous sodium carbonate. The organic phase is separated, extracted, washed with water, and purified by silica gel column chromatography, to obtain 12 g of a colorless liquid (1-b) in a quantitative yield.

References:

US9481828,2016,B2 Location in patent:Page/Page column 34; 35