1-BROMO-4-FLUORO-2-ISOPROPOXYBENZENE synthesis

3synthesis methods

Product Name:1-BROMO-4-FLUORO-2-ISOPROPOXYBENZENE
CAS Number:610797-49-4
Molecular formula:C9H10BrFO
Molecular Weight:233.08

75-30-9
255 suppliers
$15.00/1g

147460-41-1 Synthesis

147460-41-1
262 suppliers
$5.00/1g

610797-49-4
28 suppliers
$75.00/1g

Yield:610797-49-4 95%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 80; for 8 h;

Steps:

4

2-Bromo-5-fluoro-phenol Compound 4a (3.0 g, 15.7 mmol), 2-iodo-propane Compound 4b (4.0 g, 23.6 mmol), K₂CO₃(3.3 g, 23.6 mmol) and DMF (50 mL) were heated and stirred at 80° C. for 8 hrs. The excess DMF was removed under reduced pressure and the white residue was mixed with AcOEt (100 mL), washed with water and dried (Na₂SO₄). The filtered dry solution was evaporated to provide 1-bromo-4-fluoro-2-isopropoxy-benzene Compound 4c (3.48 g, 95%) as a yellowish oil.

References:

US2006/217419,2006,A1 Location in patent:Page/Page column 35