1-BROMODIFLUOROMETHYL-IMIDAZOLE synthesis
1synthesis methods
- Product Name:1-BROMODIFLUOROMETHYL-IMIDAZOLE
- CAS Number:328406-16-2
- Molecular formula:C4H3BrF2N2
- Molecular Weight:196.982
Yield:328406-16-2 78%
Reaction Conditions:
Stage #1: 1H-imidazolewith tetrabutylammomium bromide;sodium hydride in N,N-dimethyl-formamide at 0;
Stage #2: dibromodifluoromethane in N,N-dimethyl-formamide at 0 - 25; for 4 h;
References:
Sokolenko;Petko;Yagupolskii [Chemistry of Heterocyclic Compounds,2009,vol. 45,# 4,p. 430 - 435] Location in patent:experimental part