1-(bromomethyl)-2-methyl-4-nitrobenzene synthesis
- Product Name:1-(bromomethyl)-2-methyl-4-nitrobenzene
- CAS Number:22162-14-7
- Molecular formula:C8H8BrNO2
- Molecular Weight:230.06
22162-15-8
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Yield:22162-14-7 48%
Reaction Conditions:
with carbon tetrabromide;triphenylphosphine in dichloromethane at 0 - 20; for 3 h;
Steps:
s27.2 Step 2: Synthesis of 1-(bromomethyl)-2-methyl-4-nitrobenzene.
To a solution of (2-methyl-4-nitrophenyl)methanol (9.0 g, 53.84 mmol) in CH2Cl2 (100.0 mL) was added PPh3 (21.2 g, 80.76 mmol) and CBr4 (26.8 g, 80.76 mmol) at 0^ . The resulting mixture was stirred at room temperature for 3 h. After the reaction was completed, the resulting mixture was concentrated under reduced pressure. The residue was purified by flash column chromatography with petroleum ether/ethyl acetate (87/13, v/v) to afford 1-(bromomethyl)-2-methyl-4-nitrobenzene (6.0 g, 48%) as a yellow solid.
References:
WO2022/6386,2022,A1 Location in patent:Paragraph 0471-0472
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