ChemicalBook CAS DataBase List 1-BROMOMETHYL-ISOQUINOLINE

1-BROMOMETHYL-ISOQUINOLINE synthesis

3synthesis methods

Product Name:1-BROMOMETHYL-ISOQUINOLINE
CAS Number:74417-44-0
Molecular formula:C10H8BrN
Molecular Weight:222.08

1721-93-3
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$19.00/1g

74417-44-0
60 suppliers
$38.00/100mg

Yield:74417-44-0 18%

Reaction Conditions:

with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethane; for 2 h;Heating / reflux;

Steps:

17-1

Preparation 17-1); 1-Bromomethyl-isoquinolineTo 1-methylisoquinoline (0.99 g, 6.91 mmol), NBS (1.35 g, 1.1 eq) and AIBN(IO mg, catalytic amount) was added CCl₄ (IS mL), which was then refluxed for 2 h. The suspended particles were removed by filtration, and washed with CCl₄. The organic layers were combined, concentrated under reduced pressure, and separated by column chromatography (30%, ethyl acetate/hexane) to give the title compound (270 mg, Yield: 18%) as a violet solid.¹H-NMR (500MHz, CDCl₃) δ 8.48(d, IH), 8.25(d, IH), 7.87(d, IH),7.75-7.67(two t, 2H), 7.65(d, IH)

References:

WO2008/16239,2008,A1 Location in patent:Page/Page column 57-58

27311-63-3
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$45.00/10mg

74417-44-0
60 suppliers
$38.00/100mg

References

4494-18-2 Synthesis

4494-18-2
112 suppliers
$88.00/250mg

74417-44-0
60 suppliers
$38.00/100mg

References