![](/CAS/GIF/1435-44-5.gif)
1-CHLORO-2,4-DIFLUOROBENZENE synthesis
- Product Name:1-CHLORO-2,4-DIFLUOROBENZENE
- CAS Number:1435-44-5
- Molecular formula:C6H3ClF2
- Molecular Weight:148.54
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Yield: 0.08 mmol , 0.02 mmol , 0.31 mmol , 0.01 mmol , 0.01 mmol , 0.01 mmol
Reaction Conditions:
with xenon difluoride;boron trifluoride diethyl etherate at 0 - 25;Cooling with ice;Reagent/catalyst;
Steps:
Reaction of substituted benzenes with xenondifluoride in the presence of boron trifluoride-diethyl ether complex in PFB (procedure A).
General procedure: A FEP or PFA reactor equipped with a Teflon-lined magnetic stir bar and connected to a gas-washing bottle was charged with substituted benzene (0.95-1.10 mmol), 1,1,1,3,3-pentafluorobutane (1-2 mL per mmol of C6H5R), and BF3 · Et2O (1.3-1.5 mmol per mmol of C6H5R). The mixture was stirred for 10-15 min at 0-5°C (ice bath), and XeF2 (1.2-1.3 mmol per mmol of C6H5R) was added in portions. After addition of each portion, the mixture was stirred for 3-5 min at 22-25°C and cooled again. When the addition was complete the dark solution was stirred for 15-30 min at 22-25°C, 10% aqueous KHCO3 was added, and the upper organic layer was separated, passed through a short column charged with silica gel (40-60 μm), and dried over MgSO4. The solution was analyzed by 19F NMR and GC/MS. The main products are given in table, and the others are listed below (GC/MS data).
References:
Bardin;Adonin, N. Yu. [Russian Journal of Organic Chemistry,2016,vol. 52,# 10,p. 1400 - 1407][Zh. Org. Khim.,2016,vol. 52,# 10,p. 1412 - 1419,8]
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