1-chloro-2-(iodomethyl)benzene synthesis

Yield:70450-40-7 84%

Reaction Conditions:

with 1-methyl-3H-imidazolium nitrate;tetra-(n-butyl)ammonium iodide at 135 - 140; for 0.075 h;Microwave irradiation;

Steps:

General procedure: A mixture of MOM-ethers (1 mmol) [Bu₄N][X](2 mmol) was added to [Hmim][NO₃] (0.4 mmol) (and exposed to MWirradiation (All reactions were carried out at 135-140 ^oC with 170 Wapplied power). After completion of the reactions (monitored by TLC, eluent:n-hexane/ethyl acetate, 5:1), the mixture was extracted with Et₂O(3×10 mL). The organic phase was dried over anhydrous Na₂SO₄and rotary evaporation afforded a residue, which was then passed through ashort pad of neutral alumina (n-hexane/ethyl acetate, 5:1, 75 mL) to obtain thehighly pure products. The spectral data were inaccordance with those reported in the literature:

References:

Noei, Jalil;Mirjafari, Arsalan [Tetrahedron Letters,2014,vol. 55,# 32,p. 4424 - 4426] Location in patent:supporting information