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1-chloro-3-(2-hydroxyethoxy)propan-2-ol synthesis
1synthesis methods
- Product Name:1-chloro-3-(2-hydroxyethoxy)propan-2-ol
- CAS Number:18371-74-9
- Molecular formula:C5H11ClO3
- Molecular Weight:154.59
Yield:18371-74-9 80.5%
Reaction Conditions:
with ethanol;diisopropylamine at 60 - 80;
Steps:
2-A example 2-A
A, a backflow device in the mixing reactor, by adding 320 ml ethanol, 1.0mol epoxychloropropane, 0.5g b isopropylamines, starting stirring, the temperature is increased to 60-80°C, slowly dropping 1.1mol glycol, the drop finishes, keeping temperature reaction 4-10h, to obtain 3-chloro-2-hydroxyethyl propoxycyclohexyl propanol reaction product, to epoxychloropropane taken into account as the conversion rate of 98.7%;
References:
CN105523945,2016,A Location in patent:Paragraph 0010