ChemicalBook CAS DataBase List 1-Chloro-3-ethylbenzene

1-Chloro-3-ethylbenzene synthesis

11synthesis methods

Product Name:1-Chloro-3-ethylbenzene
CAS Number:620-16-6
Molecular formula:C8H9Cl
Molecular Weight:140.61

136415-83-3
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$95.00/1g

620-16-6
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$60.00/500 mg

Yield:620-16-6 51 %Spectr.

Reaction Conditions:

with 5 mol% Pd/C in benzene-d6 at 130; for 24 h;Inert atmosphere;Molecular sieve;Sealed tube;

Steps:

General procedure B for decarbonylation of aliphatic aldehydes
General procedure: Dry glass reaction tube purged with argon and equipped with a magnetic stir bar was chargedwith molecular sieves (3-4 Å, 100 mg), aldehyde 1a (40 μL, 0.30 mmol), Pd/C (16 mg, 5 mol%Pd), and C6D6 (1 mL) and the sealed tube was heated at 130 °C for 24 h. The reaction mixturewas cooled to room temperature, filtered through a short pad of SiO2 to remove the catalyst, andthe SiO2 was washed with C6D6 (2 × 0.5 mL). Compound 2a was obtained, NMR yield: 78%,based on methyl benzoate as a standard.

References:

Ajdačić, Vladimir;Nikolić, Andrea;Kerner, Michael;Wipf, Peter;Opsenica, Igor M. [Synlett,2018,vol. 29,# 13,p. 1781 - 1785] Location in patent:supporting information

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