1-Chloro-1H-pyrrolo[1,2-a]pyrazine synthesis
- Product Name:1-Chloro-1H-pyrrolo[1,2-a]pyrazine
- CAS Number:136927-64-5
- Molecular formula:C7H5ClN2
- Molecular Weight:152.58
![Pyrrolo[1,2-a]pyrazin-1(2H)-one (9CI)](/CAS/GIF/136927-63-4.gif)
136927-63-4
83 suppliers
$74.00/250mg
124-38-9
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$214.00/14L
136927-64-5
93 suppliers
$51.00/100mg
Yield:136927-64-5 71%
Reaction Conditions:
with sodium hydrogencarbonate;trichlorophosphate in acetone;
Steps:
20 (A compound of formula (BB))
PREPARATION 20 1-chloropyrrolo[1,2-a]pyrazine (A compound of formula (BB)) To pyrrolo[1,2-a]pyrazin-1(2H)-one (0.35 g, 2.61 mmol) was added phosphorous oxychloride (4.0 g, 26.1 mmol). The reaction mixture was agitated for approximately 16 hours. The reaction mixture was then made alkaline by the addition of sodium bicarbonate. The reaction mixture was then extracted with hexane, washed with a saturated sodium bicarbonate solution, dried over MgSO4 and evaporated. The product was purified by recrystallization in hexane and cooled with a mixture of dry ice and acetone to give the title compound, 1-chloropyrrolo[1,2-a]pyrazine (71%), m.p. 56°-57° C.
References:
US5041442,1991,A
136927-63-4
83 suppliers
$74.00/250mg
136927-64-5
93 suppliers
$51.00/100mg