1-(chloromethyl)-2-methyl-3-phenyl-benzene synthesis

9synthesis methods

Product Name:1-(chloromethyl)-2-methyl-3-phenyl-benzene
CAS Number:84541-46-8
Molecular formula:C14H13Cl
Molecular Weight:216.71

[1,1'-Biphenyl]-3-methanamine, N,N,2-trimethyl-

57992-79-7
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1-(chloromethyl)-2-methyl-3-phenyl-benzene

84541-46-8
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$160.00/0.500g

Yield:84541-46-8 100%

Reaction Conditions:

in toluene;

Steps:

3 PREPARATION OF 3-CHLOROMETHYL-2-METHYL-[1,1'-BIPHENYL]

EXAMPLE 3 PREPARATION OF 3-CHLOROMETHYL-2-METHYL-[1,1'-BIPHENYL] Under a dry nitrogen atmosphere, 0.5 g (0.0022 mole) of N,N,2-trimethyl-[1,1'-biphenyl]-3-methanamine was dissolved in 5.5 ml of dry toluene with stirring and the solution was heated to 80° C. A solution of 0.36 g (0.0033 mole) of ethyl chloroformate in 1.1 ml of dry toluene was added dropwise during 5 minutes. The reaction mixture was stirred for 3.3 hours at 80° C., then cooled to room temperature and filtered. The solvent was removed from the filtrate under reduced pressure to give 0.5 g (100% yield) of 3-chloromethyl-2-methyl-[1,1'-biphenyl] as a light orange oil. The ¹ H and ¹³ C nmr spectra and infra red spectrum were consistent with the proposed structure.

References:

US4473709,1984,A

76350-90-8 Synthesis