ChemicalBook CAS DataBase List 1-cyclobutylpropan-1-one

1-cyclobutylpropan-1-one synthesis

7synthesis methods

Product Name:1-cyclobutylpropan-1-one
CAS Number:6704-17-2
Molecular formula:C7H12O
Molecular Weight:112.17

925-90-6 Synthesis

925-90-6
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640768-72-5 Synthesis

Cyclobutanecarboxamide, N-methoxy-N-methyl- (9CI)

640768-72-5
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$35.00/250mg

6704-17-2
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Yield:-

Reaction Conditions:

in tetrahydrofuran at 0 - 20;

Steps:

87 1-Cyclobutylpropan-l-one.

To a solution of N-methoxy-N-methylcyclobutanecarboxamide (20.0 g, 140 mmol, 1.00 eq ) in THF (100 mL) was added EtMgBr (3.00 M, 55.9 mL, 1.20 eq ) at 0 °C. The reaction mixture was stirred at RT for 2 h. The reaction was treated with sat. aqueous ammonium chloride and extracted with EtOAc. The combined organic layers were washed with water and brine, dried over NaiSCE, filtered, and concentrated under reduced pressure to afford 1- cyclobutylpropan-l-one (13.0 g, crude) as a light yellow liquid. NMR (400 MHz, CDCh): d: 3.29 - 3.22 (m, 1H), 2.40 - 2.33 (m, 2H), 2.22 - 2.11 (m, 4H), 2.04 - 1.94 (m, 2H), 1.04 (t, 7= 7.6Hz, 3H).

References:

WO2023/283453,2023,A1 Location in patent:Paragraph 0302

3721-95-7 Synthesis