ChemicalBook CAS DataBase List 1-FMOC-4-PIPERIDONE

1-FMOC-4-PIPERIDONE synthesis

5synthesis methods

Product Name:1-FMOC-4-PIPERIDONE
CAS Number:204376-55-6
Molecular formula:C20H19NO3
Molecular Weight:321.37

41979-39-9 Synthesis

41979-39-9
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$15.00/10mg

82911-69-1 Synthesis

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1
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$7.00/25g

204376-55-6
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$16.00/1g

Yield: 93%

Reaction Conditions:

with sodium carbonate in 1,4-dioxane;water at 0 - 20; for 7.5 h;

Steps:

1.1
To the stirred solution OF 4-PIPERIDONE MONOHYDROCHLORIDE hydrate (30g, 0. 2 mol) and sodium carbonate (22g, 0. 207 mol) in 300 ML water, added dropwise solution of 9- FLUORENYLMETHOXYSUCCINIMIDE (74g, 0. 22 mole) in 300 ML dioxane at 0°C over 30 min period. After 7 hrs. of stirring at room temperature, 1000 ML of chilled water was added under continuous stirring. Separated solid was filtered, washed with water (SOOML) and dried at 60°C for 6 hrs. to give 60 GM of 9-FLUORENYLMETHOXY CARBONYL-4-PIPERIDONE (yield : 93%).

References:

SANKARANARAYANAN, Alangudi WO2005/33106, 2005, A1 Location in patent:Page/Page column 61