1-HEXYLPYRIDINIUM CHLORIDE synthesis

Yield:6220-15-1 39%

Reaction Conditions:

at 85; for 24 h;

Steps:

Pyridine (0.4 mol) and 1-chlorobutane (or 1-chlorohexane or 1-chlorooctane) (0.4 mol) were placed into a 250 cm³ round bottom flask equipped with an electric heat-jacket and vigorously stirred using a magnetic stirrer for 24 h; at 75 °C ([C₄-py]Cl) or 85 °C ([C₆-py]Cl and [C₈-py]Cl). [C₄-py]Cl and [C₆-py]Cl, obtained in the form of the white solids directly after synthesis, were washed in Schlenk apparatus with diethyl ether (4 × 50 cm³) and hexane (4 × 50 cm³) and dried by nitrogen stream. [C₈-py]Cl obtained in the form of a transparent yellow, dense, and viscous liquid was cooled to room temperature and extracted by turns with diethyl ether (4 × 50 cm³) and hexane (4 × 50 cm³) and dried by nitrogen stream. Yields: 77% for [C₄-py]Cl, 39% for [C₆-py]Cl, and 52% for [C₈-py]Cl.

References:

Och?dzan-Siod?ak, Wioletta;Dziubek, Katarzyna;Siod?ak, Dawid [Journal of Molecular Liquids,2013,vol. 177,p. 85 - 93]