ChemicalBook CAS DataBase List 1-Hydroxycyclopentanecarboxylic acid.

1-Hydroxycyclopentanecarboxylic acid. synthesis

13synthesis methods

Product Name:1-Hydroxycyclopentanecarboxylic acid.
CAS Number:16841-19-3
Molecular formula:C6H10O3
Molecular Weight:130.14

1-((trimethylsilyl)oxy)cyclopentane-1-carbonitrile

25438-35-1
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16841-19-3
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Yield:16841-19-3 94%

Reaction Conditions:

with hydrogenchloride in acetic acid at 80; for 4 h;

Steps:

8

8a (3 g, 16.36 mmol 1 .00 equiv) was dissolved in acetic acid (4 mL) and concentrated hydrogen chloride (4 mL). The resulting solution was stirred for 4 h at 80 °C. The mixture was then concentrated under reduced pressure to give 8b (2 g, 94%) as a white solid, which was used without further purification.

References:

WO2013/96771,2013,A1 Location in patent:Page/Page column 100

7677-24-9 Synthesis