ChemicalBook CAS DataBase List 1-Hydroxyethylethoxypiperazine

1-Hydroxyethylethoxypiperazine synthesis

4synthesis methods

Product Name:1-Hydroxyethylethoxypiperazine
CAS Number:13349-82-1
Molecular formula:C8H18N2O2
Molecular Weight:174.24

110-85-0 Synthesis

110-85-0
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$5.00/5 g

628-89-7
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$14.00/5g

13349-82-1
451 suppliers
$5.00/1g

Yield:13349-82-1 95.1%

Reaction Conditions:

with piperazine dihydrochloride in ethanol for 10 h;Reflux;Large scale;

Steps:

5 Synthesis of N- [2- (2-hydroxyethoxy) ethyl] piperazine
Add 150 kg of 95% ethanol to the PM-RC-15 reaction tank, stir and open the feed port. Add 200 kg of piperazine bis-salt, 100 kg of piperazine to the reaction tank, dissolve it by heating, add 110 kg of chlorinated diethylene glycol, TheReaction is completed, reduced to 15-20 , centrifugal recovery of piperazine bischloride, the filtrate adjusted to pH 11, filter out sodium chloride, the filtrate vacuum distillation to collect liquid temperature of 154-160 , the top temperature of 145-148 (Yield: 95.1%) of 90 kg of N- [2- (2-hydroxyethoxy) ethyl] piperazine as a fraction (vacuum: 2 mmHg).

References:

Weinan Chang Tong Medicine Chem Technology Co.,Ltd;Chang, Shuiping CN104016945, 2016, B Location in patent:Paragraph 0039; 0040

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