1-(Hydroxymethyl)indoline-2,3-dione synthesis
- Product Name:1-(Hydroxymethyl)indoline-2,3-dione
- CAS Number:50899-59-7
- Molecular formula:C9H7NO3
- Molecular Weight:177.16
50-00-0
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91-56-5
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50899-59-7
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Yield:50899-59-7 99%
Reaction Conditions:
in methanol;Reflux;
Steps:
Synthesis of Simple N-hydroxymethyl Isatin
The N-hydroxymethyl isatin was synthesized as shown inScheme (2). 1 mmol isatin was dissolved in 20ml methanolin a flask. Then 1.2 mmol formaldehyde was added dropwise.The mixture was stirred under refluxing until the disappearanceof isatin, as evidenced by thin-layer chromatography.The solvent was removed in vacuo and the residuewas separated by column chromatography (silica gel, petroleumether/ethyl acetate = 4: 1), giving N-hydroxymethylisatin (compound 13).
References:
Chen, Gang;Hao, Xiaojiang;Wang, Ye;Mu, Shuzhen [Letters in drug design and discovery,2015,vol. 12,# 10,p. 813 - 818]
2058-74-4
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50899-59-7
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$60.00/50mg