1-IODOPROPANE-D7 synthesis

Yield:59012-23-6 26%

Reaction Conditions:

with hydrogen iodide for 17 h;Reflux;

Steps:

3.5

Step 5[00144] d7-1-iodopropane: A solution of d5-propan-1-ol (19.8 g, 295.52 mmol, 1.00 equiv.) in 45% hydroiodic acid (180 mL) was heated at reflux for about 17 hours. The organic phase was separated and washed with sodium sulfate (1 x 10 mL) and brine (1x10 mL). The resulting crude product was then purified by distillation (1 atm). The fraction collected was at 95-101 ⁰C to give the title product as a colorless liquid (5.1 g; yield = 26 %).

References:

WO2011/17108,2011,A2 Location in patent:Page/Page column 53