ChemicalBook CAS DataBase List 1-Isoquinolineacetic acid methyl ester

1-Isoquinolineacetic acid methyl ester synthesis

9synthesis methods

Product Name:1-Isoquinolineacetic acid methyl ester
CAS Number:69582-93-0
Molecular formula:C12H11NO2
Molecular Weight:201.22

1721-93-3
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$19.00/1g

616-38-6 Synthesis

616-38-6
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$5.00/5G

69582-93-0
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$120.00/50mg

Yield:69582-93-0 98%

Reaction Conditions:

Stage #1: 1-methylisoquinolinewith lithium diisopropyl amide in tetrahydrofuran;hexane at -78; for 2 h;Inert atmosphere;
Stage #2: carbonic acid dimethyl ester in tetrahydrofuran;hexane at -78; for 0.25 h;Inert atmosphere;

References:

Jiang, Xingyu;Boehm, Philip;Hartwig, John F. [Journal of the American Chemical Society,2018,vol. 140,# 4,p. 1239 - 1242] Location in patent:supporting information