1-(METHOXYMETHOXY)-4-METHYLBENZENE synthesis
- Product Name:1-(METHOXYMETHOXY)-4-METHYLBENZENE
- CAS Number:25458-49-5
- Molecular formula:C9H12O2
- Molecular Weight:152.19
Yield:25458-49-5 90%
Reaction Conditions:
with poly(4-vinylpyridine) supported copper(II) oxide nanoparticles in neat (no solvent) at 20; for 0.0833333 h;chemoselective reaction;
Steps:
General procedure for the methoxymethyl protection reactions
General procedure: A mixture of the substrate (1 mmol), dimethoxymethane(DMM) (4 mmol) and PC-NPs (12 mg) was stirred at room temperature for the appropriate time. The progress of the reaction was monitored by TLC (EtOAc: n-hexane; 1:1). After completion of the reaction, the mixture was filtered,and the solid residue was washed with Et2O (5 mL). The filtrate was washed with a saturated solution of NaHCO3 and H2O and dried over MgSO4. Evaporation of the solvent afforded the requested methoxymethyl (MOM) ether in high purity.
References:
Shirini, Farhad;Fallah-Shojaei, Abdollah;Abedini, Masoumeh;Samavi, Laleh [Journal of the Iranian Chemical Society,2016,vol. 13,# 9,p. 1699 - 1712]
