1-Methyl-1,2,3,4-tetrahydroquinazolin-2-one synthesis
- Product Name:1-Methyl-1,2,3,4-tetrahydroquinazolin-2-one
- CAS Number:19270-60-1
- Molecular formula:C9H10N2O
- Molecular Weight:162.19
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Yield:19270-60-1 91.8%
Reaction Conditions:
in N,N-dimethyl-formamide at 80; for 2 h;
Steps:
1 Example 1 Preparation of 1-Methyl-3,4-dihydroquinazoline-2(1H)-one
To 3,4-dihydroquinazoline-2(1H)-one (1.7 g, 11.6 mmol)N,N-dimethylformamide dimethyl acetal (5.5 g, 46.3 mmol) was added dropwise to the DMF solution (10 ml), and the mixture was reacted at 80 ° C for 2 h.Water (28 ml) and ethyl acetate (15 ml) were added, and the mixture was evaporated, evaporated, evaporated, evaporated, evaporated Concentrated to a crude product,The crude product was separated by column chromatography (eluent: petroleum ether: ethyl acetate = 10:1)The yield relative to 3,4-dihydroquinazoline-2(1H)-one was 91.8%.The product purity is 99.6%(mass fraction)
References:
CN108503583,2018,A Location in patent:Paragraph 0030-0032
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