1-Methyl-1H-pyrrole-2-carbaldehyde oxime synthesis

Yield:37110-15-9 100%

Reaction Conditions:

with hydroxylamine hydrochloride;sodium acetate in methanol;water;Reflux;

Steps:

19.

All of the oxime substrates used in this investigation were synthesized in quantitative yields by refluxing a mixture of 1 equiv of the corresponding ketones or aldehydes, 1.6 equiv of hydroxylamine hydrochloride, and 2.0 equiv of sodium acetate in aqueous methanol.

References:

Augustine, John Kallikat;Kumar, Rajesha;Bombrun, Agnes;Mandal, Ashis Baran [Tetrahedron Letters,2011,vol. 52,# 10,p. 1074 - 1077] Location in patent:experimental part