1-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole synthesis
- Product Name:1-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole
- CAS Number:137898-68-1
- Molecular formula:C12H16N4
- Molecular Weight:216.28
110-85-0
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Yield:137898-68-1 69%
Reaction Conditions:
at 150; for 0.5 h;
Steps:
3.2
Step 2 0.43 g (5.0 mmol) of piperazine and 0.24 g (1.0 mmol) of the compound obtained in Step 1 were placed in a dried round flask provided with nitrogen gas, followed by reacting the mixture at 150°C for 30 mins. After cooling to room temperature, the reaction mixture was acidified with IN-HCl solution and washed with dichloromethane. The water layer was treated with IN-NaOH solution and extracted with dichloromethane. The formed organic layer was dried over anhydrous magnesium sulfate and concentrated under a reduced pressure, and the resulting residue was subjected to silica gel column chromatography (dichloromethaneimethanol^il) to obtain 0.15 g of l-methyl-2-(piperazin-l-yl)-benzoimidazole (yield: 69%).
References:
WO2008/153325,2008,A1 Location in patent:Page/Page column 27
4857-06-1
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137898-68-1
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1849-02-1
62 suppliers
$34.00/250mg
137898-68-1
12 suppliers
inquiry