1-Methyl-3-nitro-1H-pyrazole-4-carboxylic acid synthesis

2synthesis methods

Product Name:1-Methyl-3-nitro-1H-pyrazole-4-carboxylic acid
CAS Number:39205-68-0
Molecular formula:C5H5N3O4
Molecular Weight:171.1109

1H-Pyrazole-4-carboxylic acid, 1-methyl-3-nitro-, ethyl ester

64182-21-4
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1-Methyl-3-nitro-1H-pyrazole-4-carboxylic acid

39205-68-0
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Yield:39205-68-0 84%

Reaction Conditions:

with lithium hydroxide in tetrahydrofuran;methanol at 20; for 1 h;

Steps:

603 Preparation of l-methyl-3-nitro-lH-pyrazol-4-amine 2,2,2-trifluoroacetate

The compound was synthesized following the approach outlined in Example 602, substituting ethyl 3-nitro-lH-pyrazole-4-carboxylate to afford the title compound (181 mg, yield: 24% 4 steps) ESI-MS: 143 [M+H]⁺

References:

WO2016/164754,2016,A1 Location in patent:Page/Page column 40

1-METHYL-3-NITRO-1H-PYRAZOLE-4-CARBONITRILE

39205-64-6
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39205-68-0
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References