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ChemicalBook CAS DataBase List 1-Methyl-3-phenylpiperazine
5271-27-2

1-Methyl-3-phenylpiperazine synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: n-butyllithium / hexane; diethyl ether / 0.17 h / -78 °C / Inert atmosphere
1.2: 0.17 h / -78 °C / Inert atmosphere
2.1: trimethylsilyl trifluoromethanesulfonate / hexane; diethyl ether / 2 h / -78 - 20 °C / Inert atmosphere

References:

Paul, Anirudra;Seidel, Daniel [Journal of the American Chemical Society,2019,vol. 141,# 22,p. 8778 - 8782]

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