1-Methyl-4-(4-nitro-1-naphthyl)piperazine synthesis

Yield:16154-63-5 96.47%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 100; for 16 h;Sealed tube;

Steps:

4 Step 4: Synthesis of 1-methyl-4-(4-nitronaphthalen-1-yl)piperazine (7-9) :

To the DMF solution (10ml) of 1-fluoro-4-nitronaphthalene (0.38g, 1.9mmol), and 1-methylpiperazine (0.298 mg, 2.98mmol), K₂CO₃ (0.790g, 5.7 mmol) was added. The resulting reaction mixture was heated to 100 °C in a sealed tube for 16 hours. TLC and LCMS of the reaction indicated complete consumption of starting material. The reaction mixture was evaporated to get crude material, which was purified by using isolera columns chromatography to afford 1-methyl-4-(4-nitronaphthalen-1-yl)piperazine (0.52g, 1.97mmol, 96.47% yield).

References:

WO2021/3417,2021,A1 Location in patent:Paragraph 00323; 00383; 00389