1-Methyl-4-nitro-1H-pyrazole-3-carboxamide synthesis

Yield:3920-39-6 100%

Reaction Conditions:

with ammonia in methanol at 50;Sealed tube;

Steps:

A solution of methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate 22 (480 mg, 2.59 mmol) in 7Mammonia (in MeOH, 8 mL) in a 25 mL sealed tube was stirred at 50 °C overnight. The solventswere evaporated under reduced pressure to give 1-methyl-4-nitro-1H-pyrazole-3-carboxamide 26(quant) as an off-white solid.

References:

Chen, Yun;Bai, Gang;Ning, Yi;Cai, Shi;Zhang, Tao;Song, Peiran;Zhou, Jinpei;Duan, Wenhu;Ding, Jian;Xie, Hua;Zhang, Huibin [European Journal of Medicinal Chemistry,2020,vol. 190,art. no. 112092] Location in patent:supporting information