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1-methyl-beta-carboline-3-carboxylic acid synthesis

11synthesis methods
16641-82-0 Synthesis
1-Methyl-β-carboline-3-carboxylic acid methyl ester

16641-82-0
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Yield:22329-38-0 97%

Reaction Conditions:

Stage #1: 1-methyl-β-carboline-3-carboxylic acid methyl esterwith water;sodium hydroxide in methanol; for 2 h;Reflux;
Stage #2: in methanol;water; pH=8;

References:

Zeng, Yong;Zhang, Yaomou;Weng, Qunfang;Hu, Meiying;Zhong, Guohua [Molecules,2010,vol. 15,# 11,p. 7775 - 7791] Location in patent:experimental part