1-METHYLCYCLOHEXANECARBOXAMIDE synthesis

5synthesis methods

Product Name:1-METHYLCYCLOHEXANECARBOXAMIDE
CAS Number:1123-24-6
Molecular formula:C8H15NO
Molecular Weight:141.21

2890-61-1 Synthesis

1-METHYL-1-CYCLOHEXANECARBOXYLIC ACID CHLORIDE

2890-61-1
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Yield:-

Reaction Conditions:

with ammonia in tetrahydrofuran;water at 0;

Steps:

25.0 g 1-Methyl-cyclohexanecarboxylic acid was refluxed in 200 ml thionylchloride for three hours. The cooled reaction mixture was evaporated in vacuo. The residue was dissolved in 200 ml tetrahydrofuran and added dropwise to 300 ml of an ice cooled 33% ammonia solution. After completion of the addition the mixture was evaporated in vacuo, the residue dissolved in 200 ml water and extracted five times with portions of 200 ml of ethyl acetate. The combined organic layers were dried over MgSO4 and the solvent removed under reduced pressure to provide 25.0 g 1-Methyl-cyclohexanecarboxylic acid amide as an oil.C8H15NO (141.21), MS (ESI): 142.2 (M+H+).

References:

US2008/261979,2008,A1 Location in patent:Page/Page column 51