1-METHYLIMIDAZOLE-D3 (RING-D3) synthesis

Yield:4166-68-1 88%

Reaction Conditions:

with water-d2;aluminium;platinum on carbon at 200; for 1 h;Microwave irradiation;

Steps:

14

Example 14 82 mg of 1-methylimidazole, 10 mg of palladium-activated carbon (5%), and 10 mg of aluminum powder were added to 3 ml of heavy water, and the resulting mixture was subjected to microwave irradiation at 200° C. for 60 minutes. ¹H-NMR measurements (CDCl₃) were carried out through the same operations as those described in Example 1. As a result, it was confirmed that the isolated yield of the deuterated compound was 88.0%. Moreover, it was confirmed that the deuteration ratios of the hydrogen atoms (1) to (3) were 94.0% ((1)-D), 98.0% ((2)-D), and 99.0% ((3)-D), respectively. Here, the hydrogen atoms (1) to (3) respectively correspond to the deuterium atoms (1) to (3) in the target product shown below.

References:

US2010/331540,2010,A1 Location in patent:Page/Page column 10