![](/CAS/20180703/GIF/1161775-91-2.gif)
1-(oxazol-2-yl)ethanol synthesis
- Product Name:1-(oxazol-2-yl)ethanol
- CAS Number:1161775-91-2
- Molecular formula:C5H7NO2
- Molecular Weight:113.11
![1-(OXAZOL-2-YL)ETHANONE](/CAS/GIF/77311-07-0.gif)
77311-07-0
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$106.00/100mg
![1-(oxazol-2-yl)ethanol](/CAS/20180703/GIF/1161775-91-2.gif)
1161775-91-2
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Yield:1161775-91-2 90%
Reaction Conditions:
with methanol;sodium tetrahydroborate at 0 - 20; for 2 h;
Steps:
At 0 °C, a solution of 1 -(oxazol-2-yl)ethanone (1.0 g, 9.00 mmol, J&W Pharmlab) in MeOH (40 mL) was treated with sodium borohydride (0.39 g, 10.31 mmol) in 2 portions. After 15 min the reaction was allowed to warm to RT for 2 h. The reaction was quenched with water (5 mL). The mixture was partitioned between brine/DCM and the aqueous layer was extracted with DCM (2 x). The combined organic layers were washed brine, dried over Na2SO4 and concentrated under reduced pressure to give 920 mg (90%) of a light-yellow oil. 1H NMR (300 MHz, CDCl3) δ ppm 7.62 (d, J=0.88 Hz, 1 H), 7.07 (s, 1 H), 4.97 (q, J=6.58 Hz, 1 H), 1.62 (d, J=6.72 Hz, 3 H). LC/MS (ESI+) m/z = 114.1 (M+H)+
References:
WO2016/22724,2016,A1 Location in patent:Page/Page column 278