1-(Oxetan-3-yl)piperidin-4-amine synthesis
- Product Name:1-(Oxetan-3-yl)piperidin-4-amine
- CAS Number:1228948-07-9
- Molecular formula:C8H16N2O
- Molecular Weight:156.23
1228948-05-7
28 suppliers
$305.00/1g
1228948-07-9
24 suppliers
$110.00/50mg
Yield:1228948-07-9 100%
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 0.25 h;
Steps:
Step 2 : l-Oxetan-3-yl-piperidin-4- lamineTo a solution of (l-oxetan-3-yl-piperidin-4-yl)-carbamic acid iert-butyl ester (134 mg. 0.52 mmol) in dichloromethane (2 mL) was added TFA (2 mL). After 15 minutes at ambient temperature the reaction mixture was concentrated in-vacuo and the residue loaded onto a 5 g SCX-2 cartridge which was washed with methanol, then 2N ammonia in methanol. Concentration of the combined basic fractions in-vacuo afforded the title compound as a colourless gum (82 mg, 100%). NMR (400 MHz, CDC13): 4.63-4.63 (m, 4H), 3.47-3.45 (m, 1H), 2.69-2.68 (m, 3H), 1.90-1.81 (m, 4H), 1.41-1.40 (m, 2H).
References:
WO2011/73263,2011,A1 Location in patent:Page/Page column 97-98
73874-95-0
448 suppliers
$10.00/250mg
1228948-07-9
24 suppliers
$110.00/50mg