ChemicalBook CAS DataBase List 1-phenethylpiperidine

1-phenethylpiperidine synthesis

15synthesis methods

Product Name:1-phenethylpiperidine
CAS Number:332-14-9
Molecular formula:C13H19N
Molecular Weight:189.3

24815-46-1 Synthesis

Ethanethione,2-phenyl-1-(1-piperidinyl)-

24815-46-1
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332-14-9
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Yield: 93%

Reaction Conditions:

with bromopentacarbonylmanganese(I);hydrogen;triethylamine;copper(I) bromide at 100; under 22502.3 Torr; for 1 h;Autoclave;

Steps:

6
Into a 14mL polytetrafluoroethylene lined reaction tube, add the catalyst pentacarbonyl manganese bromide (0.0375mmol, 10.3mg) and the reaction substrate N-thiophenacetylpiperidine (0.5mmol, 109.5mg) in sequence, and bromide Cuprous (1.25mmol, 180mg), solvents hexafluoroisopropanol (2.5mL) and triethylamine (1.5mmol, 151.5mg), the reaction tube is placed in the autoclave and filled with 3MPa hydrogen.React at 100° C., after 1 hour, cool to room temperature, release gas, rinse the reaction tube with ethyl acetate, pass through a short silica gel column, and spin dry.Purified by column chromatography (eluent: petroleum ether: triethylamine=40/1, v/v), 88 mg of the target product (formula I-f) was obtained, and the yield was 93%.

References:

CN113061121, 2021, A Location in patent:Paragraph 0044-0048