1-Phthalazinamine, 6-bromo- synthesis

Yield:918811-38-8 89%

Reaction Conditions:

with ammonia in ethylene glycol at 130;

Steps:

134.134F

A solution of 134E (200 mg, 0.83 mmol) in saturated ammonia solution in ethylene glycol (3 mL) was heated to 130° C. overnight in a pressure tube. The reaction mixture was concentrated and the residue was chromatographed (silica gel, chloroform, 5% methanol in chloroform) to give 134F (164 mg, 89%). LC-MS m/z: 226.2 (M+H)⁺.

References:

US2007/3539,2007,A1 Location in patent:Page/Page column 106