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1-Piperidinecarbonitrile,3-methyl-(9CI) synthesis

2synthesis methods
53152-98-0 Synthesis
3-methylpiperidine, (±)

53152-98-0
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1-Piperidinecarbonitrile,3-methyl-(9CI)

150932-26-6
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Yield:150932-26-6 970 mg

Reaction Conditions:

with potassium carbonate in acetone at 0 - 20;

Steps:

15 Synthesis of 3-methylpiperidine-1-carbonitrile (A32):

To a stirred solution of 3-methylpiperidine (1.0 g, 10.08 mmol) in acetone (20 mL) at 0 °C was added K2CO3 (1.67 g, 12.1 mmol) and cyanogen bromide (1.07 g, 10.08 mmol). The reaction mixture was warmed to room temperature and stirred for 2 hours. The reaction mixture was concentrated, treated with water (30 mL), and extracted with ethyl acetate (2 x 50 mL). The organic layer was washed with brine (30 mL), dried over anhydrous Na2SO4, and concentrated to afford A32 (970 mg) as a liquid. The compound was used in the next step without further purification.

References:

WO2022/231872,2022,A1 Location in patent:Paragraph 00174-00175

53152-98-0 Synthesis
3-methylpiperidine, (±)

53152-98-0
1 suppliers
inquiry

1-Piperidinecarbonitrile,3-methyl-(9CI)

150932-26-6
3 suppliers
inquiry

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