ChemicalBook CAS DataBase List 1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID

1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID synthesis

4synthesis methods

Product Name:1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID
CAS Number:93913-86-1
Molecular formula:C11H14N2O2
Molecular Weight:206.24

1570-45-2 Synthesis

1570-45-2
377 suppliers
$7.00/10g

7379-35-3 Synthesis

7379-35-3
415 suppliers
$5.00/1g

1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID

93913-86-1
66 suppliers
$45.00/50mg

Yield:-

Reaction Conditions:

with triethylamine in ethanol;water at 150; for 96 h;

Steps:

131 Reference Example 131: 1-(Pyridin-4-yl)piperidin-4-carboxylic acid

4-Chloropyridine hydrochloride (9.55 g) and triethylamine (26.0 ml) are dissolved in ethanol (10 ml) and water (30 ml), thereto is added ethyl isonicotinate (10.00 g), and then the reaction solution is heated at 150°C for 96 hours in a sealed tube. After allowing to cool, ethanol is added to the reaction solution and the insoluble materials are removed by filtration. The filtrate is concentrated under reduced pressure, the resulting residue is suspended in chloroform, the precipitates are collected by filtration and recrystallized from water-N,N-dimethylformamide to give the title compound (10.34 g). APCI-MS M/Z:207[M+H]+.

References:

EP1489078,2004,A1 Location in patent:Page 186

1126-09-6 Synthesis