1-Pyrrolidineethanol,hydrochloride (1:1) synthesis
- Product Name:1-Pyrrolidineethanol,hydrochloride (1:1)
- CAS Number:30727-31-2
- Molecular formula:C6H14ClNO
- Molecular Weight:151.6345
![Pyrrolidine, 1-[2-(3,5-difluorophenoxy)ethyl]-](/CAS/20210305/GIF/660432-42-8.gif)
Yield:660432-42-8 50%
Reaction Conditions:
with caesium carbonate;sodium iodide in DMF (N,N-dimethyl-formamide) at 20;
Steps:
91.A Preparation 91; 2, [6-DIFLUORO-4- (PYRROLIDIN-1-YL-ETHOXY)-BENZALDEHYDE]; A. [1-(35-DIFLUORO-PHENOXAMETHYL)-PYRROLIDINE]
Add [PYRROLIDIN-1-YL-ETHANOL] hydrochloride (1.5 g) to a mixture of 3,5- difluorophenol (1.0 g), cesium carbonate (8. [78] g), sodium iodide (1.15 g) in dry dimethylformamide (20 mL). Stir at room temperature overnight. Concentrate under reduced pressure and the residue is purified by chromatography eluting with ethyl acetate: hexane (1: 1) to provide (0.8 g, 50%) of an oil.
References:
WO2004/14900,2004,A1 Location in patent:Page 50-51
