1-(THIEN-2-YLCARBONYL)PIPERAZINE synthesis

9synthesis methods

Product Name:1-(THIEN-2-YLCARBONYL)PIPERAZINE
CAS Number:52063-83-9
Molecular formula:C9H12N2OS
Molecular Weight:196.27

tert-butyl 4-(thiophen-2-ylcarbonyl)piperazine-1-carboxylate

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Yield:52063-83-9 94%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 3 h;

Steps:

PREPARATION OF PIPERAZINE-1-YL-THIOPHEN-2-YL-METHANONE (COMPOUND 595-04)

To a solution of 595-03 (3.5 g, 11.8 mmol) in dichloromethane (50 mL) was added TRIFLUOROACETIC acid (10 mL). The solution was stirred at room temperature for 3 h. The solvent was evaporated under vacuum and the residue was dissolved in chloroform. The organic phase was washed by saturated solution of sodium bicarbonate, dried over NA2SO4 and evaporated to get 2.20 g (94%) of brown viscous OIL. 1H NMR (DMSO-d6) : d 2.78 (m, 4H), 3.59 (m, 4H), 7.12 (t, J= 4.1, 1H), 7. 38 (d, J= 4.1 Hz, 1H), 7.74 (d, J= 4.8 Hz, 1H). EIMS M/Z 197 (M+1).

References:

WO2004/74218,2004,A2 Location in patent:Page 89

110-85-0 Synthesis