1-(Trifluoromethyl)cyclohexanamine hydrochloride synthesis

3synthesis methods

Product Name:1-(Trifluoromethyl)cyclohexanamine hydrochloride
CAS Number:1311315-20-4
Molecular formula:C7H13ClF3N
Molecular Weight:203.63

N-Menzyl-1-(trifluoromethyl)cyclohexan-1-amine

1100246-29-4
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1-(Trifluoromethyl)cyclohexanamine hydrochloride

1311315-20-4
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Yield:1311315-20-4 91%

Reaction Conditions:

Stage #1: N-benzyl-1-(trifluoromethyl)cyclohexanaminewith formic acid;10% Pd/C;hydrogen in methanol at 45; for 12 h;
Stage #2: with hydrogenchloride in diethyl ether;Inert atmosphere;

References:

Sch?fer, Gabriel;Matthey, Coraline;Bode, Jeffrey W. [Angewandte Chemie - International Edition,2012,vol. 51,# 36,p. 9173 - 9175] Location in patent:supporting information

4471-09-4
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1311315-20-4
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References

108-94-1 Synthesis

108-94-1
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$12.00/50g

1311315-20-4
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References