Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester synthesis

5synthesis methods

Product Name:Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester
CAS Number:1006037-11-1
Molecular formula:C26H24F3NO3S
Molecular Weight:487.53

1006037-10-0 Synthesis

Benzoic acid, 4-(1-isocyanatocyclopropyl)-, Methyl ester

1006037-10-0
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Thiophene, 2,5-diMethyl-3-[[4-(trifluoroMethyl)phenyl]Methyl]-

1006037-09-7
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Benzoic acid, 4-[1-[[[2,5-diMethyl-4-[[4-(trifluoroMethyl)phenyl]Methyl]-3-thienyl]carbonyl]aMino]cyclopropyl]-, Methyl ester

1006037-11-1
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Yield:1006037-11-1 90 mg

Reaction Conditions:

with iron(III) chloride in 1,2-dichloro-ethane at 50; for 0.25 h;Inert atmosphere;Friedel-Crafts amidation;

References:

Gauvreau, Danny;Dolman, Sarah J.;Hughes, Greg;Oshea, Paul D.;Davies, Ian W. [Journal of Organic Chemistry,2010,vol. 75,# 12,p. 4078 - 4085] Location in patent:supporting information; experimental part