N-(propan-2-yl)-N'-[1-(propan-2-yl)-1H-pyrazol-5-yl]benzenecarboximidamide synthesis

Yield:1006482-12-7 53%

Reaction Conditions:

with triethylamine in dichloromethane at 0 - 40; for 5 h;

Steps:

General Procedure for the Synthesis of Amidines 3

General procedure: To a stirred solution of aminopyrazole 1 (0.01 mol) and Et3N(1.53 mL, 0.011 mol) in CH2Cl2 (30 mL) at 0 °C a solutionof imidoyl chloride 2 (0.01 mol) in CH2Cl2 (30 mL) wasadded. The reaction mixture was left to stand for 1 h at r.t. and then heated at 40 °C for 4 h. The solvent was evaporatedin vacuo, and the residue was triturated with H2O andcrystallized from dioxane-DMF (ca. 3:1).

References:

Ryabukhin, Sergey V.;Granat, Dmitry S.;Plaskon, Andrey S.;Volochnyuk, Dmitriy M.;Shivanyuk, Alexander N. [Synlett,2013,vol. 24,# 20,art. no. ST-2013-D0759-L,p. 2675 - 2678]